Molecular-genetic testing in preoperative diagnosis and choice of surgical tactics in patients with thyroid neoplasms

The high frequency of the detection follicular thyroid tumors requires development most effective new methods for their differential diagnosis to early verification well-differentiated cancer, reduce number unjustified surgical interventions, select rational volume, and improve treatment results. use molecular genetic research in preoperative diagnostics choice tactics patients with neoplasms was substantiated. To optimize algorithm treatment, a retrospective analysis results examination 100 carried out, which supplemented by determination markers cellular material puncture fine-needle biopsy using flow fluor-cytometry polymerase chain reaction. diagnostic significance tumor marker Galectin-3, V600E mutation BRAF gene cancer assessed. prognostic value sodium iodide symporter resistance postoperative radioactive iodine therapy has been established, makes it possible substantiate need expand scope intervention. an optimized algorithm, considering this category patients, contributes individualized tactics, depending on nature pathological process.